Data from: Profile of and risk factors for post-stroke cognitive impairment in diverse ethno-regional groups
| dc.contributor.affiliation | University of New South Wales-Sachdev, Perminder S | |
| dc.contributor.author | Sachdev, Perminder S | |
| dc.coverage.spatial | USA | |
| dc.coverage.spatial | Asia | |
| dc.coverage.spatial | Europe | |
| dc.coverage.spatial | Africa | |
| dc.coverage.spatial | Australia | |
| dc.date.accessioned | 2025-04-29T14:04:49Z | |
| dc.date.issued | 2019-11-12 | |
| dc.date.issued | 2019-11-12 | |
| dc.description | OBJECTIVE: To address the variability in prevalence estimates and inconsistencies in potential risk factors for post-stroke cognitive impairment (PSCI) using a standardised approach and individual participant data (IPD) from international cohorts in the STROKOG consortium. METHODS: We harmonised data from thirteen studies based in eight countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardised cognitive domain scores. Domain-specific impairment was based on percentile cut-offs from normative groups, and associations between domain scores and risk factors were examined using one-stage IPD meta-analysis. RESULTS: In a combined sample of 3,146 participants admitted to hospital for stroke (97%) or TIA (3%), 44% were impaired in global cognition and 30–35% in individual domains 2 to 6 months after the index event. Diabetes and a history of past stroke were strongly associated with poorer cognitive function after covariate adjustments; hypertension, smoking and atrial fibrillation had weaker domain-specific associations. While there were no significant differences in domain impairment among ethno-racial groups, some inter-ethnic differences were found in the effects of risk factors on cognition. CONCLUSIONS: This paper confirms the high prevalence of PSCI in diverse populations, highlights common risk factors, in particular diabetes, and points to ethno-racial differences which warrant attention in the development of prevention strategies. | |
| dc.identifier | https://doi.org/10.5061/dryad.m517990 | |
| dc.identifier.uri | https://datakatalogi.helsinki.fi/handle/123456789/6067 | |
| dc.rights.license | cc-zero | |
| dc.subject | Vascular dementia | |
| dc.subject | consortium | |
| dc.subject | post-stroke cognitive impairment | |
| dc.subject | Dementia | |
| dc.title | Data from: Profile of and risk factors for post-stroke cognitive impairment in diverse ethno-regional groups | |
| dc.type | dataset |